The Link Between Obesity, Immune Cells, and Psoriasis

Obesity and Psoriasis: Is There a Connection?

Psoriasis, a chronic autoimmune disease causing red, scaly patches, has long been associated with obesity.

However, the underlying mechanisms have remained unclear until a recent study published in Nature.

The study found that obesity may damage immune cells that prevent psoriasis, shedding light on the association.

This discovery provides new insights into the development of psoriasis and its connection to obesity.

The Role of Immune Cells in Psoriasis

Psoriasis results from an abnormal immune response where immune cells attack healthy skin cells.

Regulatory T cells (Tregs) help maintain immune balance and prevent excessive inflammation.

The study reveals that obesity impairs the function of Tregs, leading to an immune system imbalance.

This imbalance contributes to the development or worsening of psoriasis in obese individuals.

Understanding the role of immune cells opens up new possibilities for targeted psoriasis therapies.

Obesity's Impact on Immune Cells

Experiments on mice showed that obesity reduces the number and function of Tregs.

Tregs suppress inflammation and maintain immune tolerance, but their impaired function in obesity leads to an exaggerated inflammatory response.

This response is a hallmark of psoriasis, suggesting that obesity-induced changes in immune cells contribute to its development.

Further studies are needed to validate these findings in humans and explore potential treatments.

Implications for Psoriasis Treatment

The link between obesity, immune cells, and psoriasis has significant treatment implications.

Targeting Treg dysfunction in obese individuals could help prevent or alleviate psoriasis symptoms.

Developing therapies to enhance Treg function in the context of obesity is a promising research avenue.

Furthermore, lifestyle interventions promoting weight loss and improved metabolic health could positively impact psoriasis outcomes.

Further research is necessary to uncover the precise mechanisms behind the obesity-immune cell-psoriasis association.


The study highlights a potential link between obesity, immune cells, and the development of psoriasis.

Obesity may damage Tregs, leading to an immune system imbalance and increased risk of psoriasis.

Understanding these mechanisms could pave the way for novel therapeutic approaches that target immune cell dysfunction in obese individuals.

Moreover, promoting healthy lifestyle habits and maintaining a healthy weight may have a positive impact on psoriasis prevention and management.

Further research is necessary to elucidate the precise molecular pathways involved and translate these findings into clinical applications.

References (July 20, 2023). Obesity may damage immune cells that prevent psoriasis.

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